Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location

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Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location

The p63RhoGEF and GEFT proteins are encoded by the same gene and both members of the Dbl family of guanine nucleotide exchange factors. These proteins can be activated by the heterotrimeric G-protein subunit Gαq. We show that p63RhoGEF is located at the plasma membrane, whereas GEFT is confined to the cytoplasm. Live-cell imaging studies yielded quantitative information on diffusion coefficient...

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The Impact of BK Channels on Cellular Excitability Depends on their Subcellular Location

Large conductance calcium-activated potassium channels (or BK channels) fulfil a multitude of roles in the central nervous system. At the soma of many neuronal cell types they control the speed of action potential (AP) repolarization and therefore they can have an impact on neuronal excitability. Due to their presence in nerve terminals they also regulate transmitter release. BK channels have a...

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ژورنال

عنوان ژورنال: Scientific Reports

سال: 2013

ISSN: 2045-2322

DOI: 10.1038/srep02284